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That the genetic changes have anything to do with brain size or intelligence "is totally unproven and potentially dangerous territory to get into with such sketchy data," stressed Dr.Francis Collins, director of the National Human Genome Research Institute. So suggests new research that tracked changes in two genes thought to help regulate brain growth, changes that appeared well after the rise of modern humans 200,000 years ago.

Aside from not knowing what the gene variants actually do, no one knows how precise the model Lahn used to date them is, Collins added.

Lahn's own calculations acknowledge that the microcephalin variant could have arisen anywhere from 14,000 to 60,000 years ago, and that the uncertainty about the ASPM variant ranged from 500 to 14,000 years ago.

"A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.

Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size.

In fact, the variations were so common they couldn't be accidental mutations but instead were probably due to natural selection, where genetic changes that are favorable to a species quickly gain a foothold and begin to spread, the researchers report.

Lahn offers an analogy: Medieval monks would copy manuscripts and each copy would inevitably contain errors — accidental mutations.

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